In the early 1950s, the CIA started a program called MK-ULTRA. Fearing that the Soviet Union was getting ahead in espionage, they investigated whether LSD could be used for mind control.
The existence of MK-ULTRA is fairly well-known, but most people don’t know just how crazy the details were. CIA agents did some absolutely insane things with LSD. It’s not entirely clear that the government actually learned anything, but they definitely got some incredible stories out of it.